NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts-Reference-Cited by-同舟云学术

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts

Published:2017-10-05 Issue:14 Volume:130 Page:1649-1660
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Marlein Christopher R.¹,Zaitseva Lyubov¹,Piddock Rachel E.¹,Robinson Stephen D.²,Edwards Dylan R.¹,Shafat Manar S.¹,Zhou Zhigang¹,Lawes Matthew³,Bowles Kristian M.¹³,Rushworth Stuart A.¹

Affiliation:

1. Norwich Medical School and

2. School of Biological Sciences, The University of East Anglia, Norwich Research Park, United Kingdom; and

3. Department of Haematology, Norfolk and Norwich University Hospitals NHS Trust, Norwich, United Kingdom

Abstract

Key Points Functional mitochondria are transferred in vivo from BMSC to the leukemic blast. AML-derived NOX2 drives transfer of mitochondria via the generation of superoxide.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/14/1649/1402822/blood772939.pdf

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