Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL-Reference-Cited by-同舟云学术

Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL

Published:2016-05-12 Issue:19 Volume:127 Page:2310-2321
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shukla Ashima¹,Rai Karan¹,Shukla Vipul¹,Chaturvedi Nagendra K.¹,Bociek R. Gregory²,Pirruccello Samuel J.³,Band Hamid¹³⁴,Lu Runqing¹,Joshi Shantaram S.¹

Affiliation:

1. Department of Genetics, Cell Biology and Anatomy,

2. Department of Internal Medicine, Section of Oncology and Hematology,

3. Department of Pathology and Microbiology, College of Medicine, and

4. Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha, NE

Abstract

Key Points SPRY2 is downregulated in CLL cells from patients with poor prognosis. SPRY2 is negative regulator of Syk-mediated BCR and MAPK-Erk signaling in CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/19/2310/1393325/2310.pdf

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