Late acute graft-versus-host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors

Author:

Holtan Shernan G.1,Khera Nandita2,Levine John E.3,Chai Xiaoyu4,Storer Barry4,Liu Hien D.5,Inamoto Yoshihiro6,Chen George L.7,Mayer Sebastian8,Arora Mukta1,Palmer Jeanne2,Flowers Mary E. D.4,Cutler Corey S.9,Lukez Alexander9,Arai Sally10,Lazaryan Aleksandr1,Newell Laura F.11,Krupski Christa12,Jagasia Madan H.12,Pusic Iskra13,Wood William14,Renteria Anne S.3,Yanik Gregory15,Hogan William J.16,Hexner Elizabeth17,Ayuk Francis18,Holler Ernst19,Watanaboonyongcharoen Phandee20,Efebera Yvonne A.21,Ferrara James L. M.3,Panoskaltsis-Mortari Angela1,Weisdorf Daniel1,Lee Stephanie J.4,Pidala Joseph22

Affiliation:

1. Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN;

2. Mayo Clinic, Phoenix, AZ;

3. Blood and Marrow Transplantation Program, The Icahn School of Medicine at Mount Sinai, New York, NY;

4. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

5. Blood and Marrow Transplant Program, Cleveland Clinic, Cleveland, OH;

6. Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan;

7. Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY;

8. Department of Medicine, Weill Cornell Medical Center, New York, NY;

9. Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

10. Division of Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, CA;

11. Center for Hematologic Malignancies, Oregon Health and Science University, Portland, OR;

12. Division of Hematology/Oncology, Stem Cell Transplantation, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN;

13. Medical Oncology, Washington University Medical Center, St. Louis, MO;

14. Hematology/Oncology, University of North Carolina Healthcare, Chapel Hill, NC;

15. Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI;

16. Blood and Marrow Transplantation Program, Mayo Clinic, Rochester, MN;

17. Abramson Cancer Center, University of Pennsylvania, Philadelphia PA;

18. Department of Stem Cell Transplantation, University Medical Center, Hamburg-Eppendorf, Germany;

19. Blood and Marrow Transplantation Program, University of Regensburg, Regensburg, Germany;

20. Blood and Marrow Transplantation Program, Chulalongkorn University, Bangkok, Thailand;

21. Blood and Marrow Transplantation Program, Ohio State University, Columbus, OH; and

22. Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL

Abstract

Key Points Under current treatment approaches, patients with LA GVHD have poor overall and failure-free survival. Levels of AREG are elevated in LA GVHD, and the AREG/EGF ratio is predictive of overall survival and nonrelapse mortality in LA GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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