Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells

Author:

Kariminia Amina1,Holtan Shernan G.2,Ivison Sabine1,Rozmus Jacob1,Hebert Marie-Josée3,Martin Paul J.4,Lee Stephanie J.4,Wolff Daniel5,Subrt Peter1,Abdossamadi Sayeh1,Sung Susanna1,Storek Jan6,Levings Megan1,Aljurf Mahmoud7,Arora Mukta2,Cutler Corey8,Gallagher Geneviève9,Kuruvilla John10,Lipton Jeff10,Nevill Thomas J.11,Newell Laura F.12,Panzarella Tony10,Pidala Joseph13,Popradi Gizelle14,Szwajcer David15,Tay Jason16,Toze Cynthia L.11,Walker Irwin17,Couban Stephen18,Storer Barry E.4,Schultz Kirk R.1

Affiliation:

1. Michael Cuccione Childhood Cancer Research Program, British Columbia Children’s Hospital/University of British Columbia, Vancouver, BC, Canada;

2. Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN;

3. Centre de Recherche du Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, University of Montreal, Montreal, QC, Canada;

4. Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA;

5. Department of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany;

6. University of Calgary, Calgary, AB, Canada;

7. King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia;

8. Dana-Farber Cancer Institute, Boston, MA;

9. Centre Hospitalier Universitaire de Quebec, Hopital Enfant-Jesus, Quebec City, QC, Canada;

10. Princess Margaret Cancer Centre, Toronto, ON, Canada;

11. Leukemia/Bone Marrow Transplant Program of British Columbia, Vancouver General Hospital, British Columbia Cancer Agency and University of British Columbia, Vancouver, BC, Canada;

12. Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health & Science University, Portland, OR;

13. H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL;

14. McGill University Health Center, Montreal, QC, Canada;

15. CancerCare Manitoba, Winnipeg, MB, Canada;

16. Ottawa Hospital Research Institute, Ottawa, ON, Canada;

17. Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada; and

18. Queen Elizabeth II Health Science Centre, Halifax, NS, Canada

Abstract

Key Points There is a high level of heterogeneity in cGVHD plasma biomarkers in a large cGVHD cohort, with CXCL10 being the most reproducible marker. CXCR3+CD56bright natural killer regulatory cells have a strong inverse relationship with plasma CXCL10 in patients with or without cGVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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