Runx1 downregulates stem cell and megakaryocytic transcription programs that support niche interactions

Author:

Behrens Kira1,Triviai Ioanna12,Schwieger Maike3,Tekin Nilgün14,Alawi Malik56,Spohn Michael5,Indenbirken Daniela5,Ziegler Marion1,Müller Ursula1,Alexander Warren S.78,Stocking Carol1

Affiliation:

1. Retroviral Pathogenesis, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;

2. Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

3. Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

4. Biotechnology Institute, University of Ankara, Ankara, Turkey;

5. Virus Genomics, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany;

6. Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;

7. Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia; and

8. Department of Medical Biology, The University of Melbourne, VIC, Australia

Abstract

Key Points Runx1 is a key determinant of megakaryocyte cell-fate decisions in multipotent progenitors. Runx1 downregulates cell-adhesion factors that promote residency of stem cells and megakaryocytes in their bone marrow niche.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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