CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation-Reference-Cited by-同舟云学术

CD4+ T-cell alloreactivity toward mismatched HLA class II alleles early after double umbilical cord blood transplantation

Published:2016-10-27 Issue:17 Volume:128 Page:2165-2174
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lamers Cor H. J.¹^ORCID,Wijers Rebecca¹,van Bergen Cornelis A. M.²^ORCID,Somers Judith A. E.³⁴,Braakman Eric³,Gratama Jan Willem¹,Debets Reno¹^ORCID,Falkenburg J. H. Frederik²^ORCID,Cornelissen Jan J.³

Affiliation:

1. Laboratory of Tumor Immunology, Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands;

2. Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands;

3. Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands; and

4. Department of Transfusion Medicine, Sanquin Blood Supply, Rotterdam, The Netherlands

Abstract

Key Points Graft-versus-graft alloreactivity after dUCBT involves recognition of mismatched HLA class II alleles by allele-specific CD4+ effector T cells. Alloreactive donor CD4+ T cells may recognize recipient leukemia if mismatched for individual HLA class II alleles.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/17/2165/1396487/2165.pdf

Reference43 articles.

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4. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia.;Rocha;N Engl J Med,2004

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