Phase 1 trial of rituximab, lenalidomide, and ibrutinib in previously untreated follicular lymphoma: Alliance A051103

Author:

Ujjani Chaitra S.1,Jung Sin-Ho2,Pitcher Brandelyn2,Martin Peter3,Park Steven I.4,Blum Kristie A.5,Smith Sonali M.6,Czuczman Myron7,Davids Matthew S.8,Levine Ellis7,Lewis Lionel D.9,Smith Scott E.10,Bartlett Nancy L.11,Leonard John P.3,Cheson Bruce D.1

Affiliation:

1. Lombardi Comprehensive Cancer Center, Medstar Georgetown University Hospital, Washington, DC;

2. Alliance Statistics and Data Center, Duke University, Durham, NC;

3. Meyer Cancer Center, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY;

4. UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC;

5. Division of Hematology, The Ohio State University, Columbus, OH;

6. University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL;

7. Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, NY;

8. Dana-Farber/Partners CancerCare, Boston, MA;

9. Norris Cotton Cancer Center, The Geisel School of Medicine at Dartmouth, Lebanon, NH;

10. Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL; and

11. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO

Abstract

Key Points The combination of rituximab, lenalidomide, and ibrutinib is associated with a high incidence of rash in follicular lymphoma (all grades 82%). Efficacy of the triplet appears similar to rituximab-lenalidomide in the same patient population.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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