A novel human B cell subpopulation representing the initial germinal center population to express AID-Reference-Cited by-同舟云学术

A novel human B cell subpopulation representing the initial germinal center population to express AID

Published:2006-11-28 Issue:6 Volume:109 Page:2545-2552
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kolar Grant R.¹,Mehta Darshna¹,Pelayo Rosana²,Capra J. Donald¹

Affiliation:

1. Program in Molecular Immunogenetics and

2. Program in Immunobiology and Cancer, Oklahoma Medical Research Foundation, Oklahoma City, OK

Abstract

Abstract We have identified a novel mature human B-cell subpopulation in the human tonsil that has characteristics of both naive B cells and germinal center B cells including the expression of activation-induced cytidine deaminase (AID), which is essential for the process of immunoglobulin somatic hypermutation and class-switch recombination. These cells are clearly somatically hypermutated, albeit modestly. Their phenotype (IgD+CD38−CD23−FSChiCD71+) is unique and suggests they may be intermediate between both naive and germinal center cells. Morphologically they are also distinct from other B-cell subpopulations. The evidence presented suggests these cells may be the founder cells of the germinal center reaction (a pro-GC cell) and may be the normal counterpart of the mantle cell lymphoma cell.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/109/6/2545/1477630/zh800607002545.pdf

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