Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells-Reference-Cited by-同舟云学术

Continuous blockade of CXCR4 results in dramatic mobilization and expansion of hematopoietic stem and progenitor cells

Published:2017-05-25 Issue:21 Volume:129 Page:2939-2949
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Karpova Darja¹,Ritchey Julie K.¹,Holt Matthew S.¹,Abou-Ezzi Grazia¹,Monlish Darlene²,Batoon Lena³,Millard Susan³,Spohn Gabriele⁴,Wiercinska Eliza⁴,Chendamarai Ezhil¹,Yang Wei⁵,Christ Stephanie¹,Gehrs Leah¹,Schuettpelz Laura G.²,Dembowsky Klaus⁶,Pettit Allison R.³,Rettig Michael P.¹,Bonig Halvard⁴⁷,DiPersio John F.¹

Affiliation:

1. Division of Oncology, Department of Medicine, and

2. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO;

3. Mater Research Institute, The University of Queensland, Faculty of Medicine, Translational Research Institute, Woolloongabba, QLD, Australia;

4. German Red Cross Blood Service and Institute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany;

5. Genome Technology Access Center, Washington University, St. Louis, MO;

6. Amcure GmbH, Munich, Germany; and

7. Division of Hematology, Department of Medicine, University of Washington, Seattle, WA

Abstract

Key Points Prolonged inhibition of CXCR4/CXCL12 signaling results in exceptional mobilization along with an expansion of the BM HSPC pool. Reversible inhibition of the CXCR4/CXCL12 axis may represent a novel strategy to restore damaged BM.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/21/2939/1401336/blood746909.pdf

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