Determinants of fatal bleeding during induction therapy for acute promyelocytic leukemia in the ATRA era

Author:

Mantha Simon1,Goldman Debra A.2,Devlin Sean M.2,Lee Ju-Whei3,Zannino Diana4,Collins Marnie4,Douer Dan5,Iland Harry J.6,Litzow Mark R.7,Stein Eytan M.5,Appelbaum Frederick R.8,Larson Richard A.9,Stone Richard10,Powell Bayard L.11,Geyer Susan12,Laumann Kristina13,Rowe Jacob M.14,Erba Harry15,Coutre Steven16,Othus Megan17,Park Jae H.5,Wiernik Peter H.18,Tallman Martin S.5

Affiliation:

1. Department of Medicine, Hematology Service, and

2. Department of Epidemiology-Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY;

3. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Biostatistics Center, Boston, MA;

4. Centre for Biostatistics and Clinical Trials, Peter MacCallum Cancer Center, East Melbourne, Australia;

5. Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY;

6. Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, Australia;

7. Department of Hematology, Mayo Clinic, Rochester, MN;

8. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

9. Section of Hematology/Oncology, University of Chicago, Chicago, IL;

10. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;

11. Section on Hematology and Oncology, Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC;

12. Health Informatics Institute, University of South Florida, Tampa, FL;

13. Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN;

14. Department of Hematology, Rambam Medical Center, Haifa, Israel;

15. Division of Hematology and Oncology, University of Alabama School of Medicine, Birmingham, AL;

16. Division of Hematology, Stanford University School of Medicine, Stanford, CA;

17. Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

18. Cancer Research Foundation, Chappaqua, NY

Abstract

Key Points High WBC is an independent predictor of early HD in APL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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