Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease–associated thrombosis in mice-Reference-Cited by-同舟云学术

Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease–associated thrombosis in mice

Published:2017-05-11 Issue:19 Volume:129 Page:2667-2679
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yang Ke¹²,Du Changhong²,Wang Xinmiao²,Li Fengju²,Xu Yang²,Wang Song²,Chen Shilei²,Chen Fang²,Shen Mingqiang²,Chen Mo²,Hu Mengjia²,He Ting¹,Su Yongping²,Wang Junping²,Zhao Jinghong¹

Affiliation:

1. Department of Nephrology, Xinqiao Hospital, Third Military Medical University, Chongqing, China; and

2. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Chongqing, China

Abstract

Key Points Uremic solute IS increases platelet activity via activation of ROS/p38MAPK signaling. Klotho counteracts IS-induced thrombosis by restraining platelet hyperactivity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/19/2667/1400522/blood744060.pdf

Reference55 articles.

1. Chronic kidney disease: the global challenge;Meguid El Nahas;Lancet,2005

2. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization;Go;N Engl J Med,2004

3. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis;Matsushita;Lancet,2010

4. Atherosclerosis in CKD: differences from the general population;Drüeke;Nat Rev Nephrol,2010

5. Platelet alpha-granule proteins: studies on release and subcellular localization;Kaplan;Blood,1979

Cited by 115 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Platelets, inflammation, and purinergic receptors in chronic kidney disease;Kidney International;2024-09

2. Microbiota alterations associated with vascular diseases: postbiotics as a next-generation magic bullet for gut-vascular axis;Pharmacological Research;2024-09

3. Anti-Inflammatory Role of the Klotho Protein and Relevance to Aging;Cells;2024-08-24

4. Rejuvenation of young blood on aging organs: Effects, circulating factors, and mechanisms;Heliyon;2024-06

5. Indoxyl Sulfate-Induced Macrophage Toxicity and Therapeutic Strategies in Uremic Atherosclerosis;Toxins;2024-05-31