Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B
Author:
Affiliation:
1. IRSD (Institut de Recherche en Santé Digistive), Université de Toulouse, INSERM, INRA, ENVT, UPS, Toulouse, France; and
2. Laboratoire de Bactériologie-Hygiène, CHU Toulouse, Toulouse, France
Publisher
American Society of Hematology
Subject
Cell Biology,Hematology,Immunology,Biochemistry
Link
http://ashpublications.org/blood/article-pdf/129/4/533/1401628/blood748541.pdf
Reference14 articles.
1. Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling;Besson-Fournier;Blood,2012
2. Activin B induces noncanonical SMAD1/5/8 signaling via BMP type I receptors in hepatocytes: evidence for a role in hepcidin induction by inflammation in male mice;Canali;Endocrinology,2016
3. Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction;Vassalli;Genes Dev,1994
4. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo;Pietrangelo;Gastroenterology,2007
5. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation;Verga Falzacappa;Blood,2007
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