First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation-Reference-Cited by-同舟云学术

First report of donor cell–derived acute leukemia as a complication of umbilical cord blood transplantation

Published:2005-12-15 Issue:13 Volume:106 Page:4377-4380
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Fraser Christopher J.¹,Hirsch Betsy A.¹,Dayton Vanessa¹,Creer Michael H.¹,Neglia Joseph P.¹,Wagner John E.¹,Baker K. Scott¹

Affiliation:

1. From the Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota; the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN; and the Departments of Pathology and Pediatrics, St Louis University, St Louis, MO.

Abstract

Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation. A 12-month-old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. Forty months after transplantation, he developed acute myeloid leukemia. Cytogenetic and molecular analysis confirmed donor cell origin. The Cord Blood Bank (CBB) contacted the donor's family and established that the child, now 7 years old, was healthy. This represents the first reported case of donor cell leukemia following UCBT. This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/106/13/4377/465118/zh802405004377.pdf

Reference25 articles.

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