New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Published:2017-09-21 Issue:12 Volume:130 Page:1395-1401
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lilljebjörn Henrik¹^ORCID,Fioretos Thoas¹²^ORCID

Affiliation:

1. Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden, and

2. Department of Clinical Genetics, University and Regional Laboratories Region Skåne, Lund, Sweden

Abstract

Abstract Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/12/1395/1402651/blood742643.pdf

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