New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia-Reference-Cited by-同舟云学术

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia

Published:2017-09-21 Issue:12 Volume:130 Page:1395-1401
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lilljebjörn Henrik¹^ORCID,Fioretos Thoas¹²^ORCID

Affiliation:

1. Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden, and

2. Department of Clinical Genetics, University and Regional Laboratories Region Skåne, Lund, Sweden

Abstract

Abstract Until recently, 20% to 30% of pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) could not be classified into any of the established molecular subtypes. Recent molecular studies of such cases have, however, further clarified their mutational spectrum and identified new oncogenic subtypes consisting of cases with DUX4 rearrangements, ETV6-RUNX1–like gene expression, MEF2D rearrangements, and ZNF384 rearrangements. In this review, we describe these new subtypes, which account for up to 50% of previously unclassified pediatric BCP-ALL cases.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/12/1395/1402651/blood742643.pdf

Reference52 articles.

1. Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis;Secker-Walker;BMJ,1978

2. Chromosomal abnormalities and their clinical significance in acute lymphoblastic leukemia. Third International Workshop on Chromosomes in Leukemia;Cancer Res,1983

3. Pre-B cell leukemia associated with chromosome translocation 1;19;Carroll;Blood,1984

4. New chromosomal translocations correlate with specific immunophenotypes of childhood acute lymphoblastic leukemia;Williams;Cell,1984

5. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia;Smith;J Clin Oncol,1996

Cited by 77 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Exploration of the intracellular chiral metabolome in pediatric BCP-ALL: a pilot study investigating the metabolic phenotype of IgH locus aberrations;Frontiers in Oncology;2024-08-05

2. RNASeq Analysis for Accurate Identification of Fusion Partners in Tumor Specific Translocations Detected by Standard FISH Probes in Hematologic Malignancies;Clinical Pathology;2024-01

3. Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis;Blood Cancer Discovery;2023-12-27

4. Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia;npj Precision Oncology;2023-12-08

5. Novel Biomarkers and Molecular Targets in ALL;Current Hematologic Malignancy Reports;2023-12-04