Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients-Reference-Cited by-同舟云学术

Synergy of BCL2 and histone deacetylase inhibition against leukemic cells from cutaneous T-cell lymphoma patients

Published:2017-11-09 Issue:19 Volume:130 Page:2073-2083
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cyrenne Benoit M.¹,Lewis Julia M.¹,Weed Jason G.¹,Carlson Kacie R.¹,Mirza Fatima N.¹,Foss Francine M.²,Girardi Michael¹^ORCID

Affiliation:

1. Department of Dermatology and

2. Internal Medicine (Medical Oncology), Yale School of Medicine, New Haven, CT

Abstract

Key PointsThe antiapoptotic protein BCL2 is a promising potential target in the treatment of CTCL. Combination inhibition of BCL2 and HDACs leads to efficient killing of CTCL cells due to the synergistic activation of apoptosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/19/2073/1403292/blood792150.pdf

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