Decitabine enhances targeting of AML cells by CD34+ progenitor-derived NK cells in NOD/SCID/IL2Rgnull mice-Reference-Cited by-同舟云学术

Decitabine enhances targeting of AML cells by CD34+ progenitor-derived NK cells in NOD/SCID/IL2Rgnull mice

Published:2018-01-11 Issue:2 Volume:131 Page:202-214
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Cany Jeannette¹,Roeven Mieke W. H.¹²,Hoogstad-van Evert Janneke S.¹³,Hobo Willemijn¹,Maas Frans¹,Franco Fernandez Rosalia¹,Blijlevens Nicole M. A.²,van der Velden Walter J.²,Huls Gerwin⁴,Jansen Joop H.¹,Schaap Nicolaas P. M.²,Dolstra Harry¹

Affiliation:

1. Department of Laboratory Medicine, Laboratory of Hematology,

2. Department of Hematology, and

3. Department of Gynecology, Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands; and

4. Department of Hematology, University Medical Center Groningen, Groningen, The Netherlands

Abstract

Key Points CD34+ progenitor-derived NK cells and HMAs potently cooperate against AML cells. DAC-mediated modulation of CD34-derived NK cell phenotype, function, and trafficking results in enhanced anti-leukemic effect in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/2/202/1406012/blood790204.pdf

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