The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV-Reference-Cited by-同舟云学术

The same site on the integrase-binding domain of lens epithelium–derived growth factor is a therapeutic target for MLL leukemia and HIV

Published:2014-12-11 Issue:25 Volume:124 Page:3730-3737
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Murai Marcelo J.¹,Pollock Jonathan¹,He Shihan¹,Miao Hongzhi¹,Purohit Trupta¹,Yokom Adam¹,Hess Jay L.¹,Muntean Andrew G.¹,Grembecka Jolanta¹,Cierpicki Tomasz¹

Affiliation:

1. Department of Pathology, University of Michigan, Ann Arbor, MI

Abstract

Key Points Inhibiting LEDGF interaction with a novel fragment of MLL represents an attractive approach to develop new drugs for MLL leukemias. Structural studies reveal a new pocket on the LEDGF IBD suitable for targeting by small-molecule inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/25/3730/1465281/3730.pdf

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