TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain-Reference-Cited by-同舟云学术

TFPI cofactor function of protein S: essential role of the protein S SHBG-like domain

Published:2014-06-19 Issue:25 Volume:123 Page:3979-3987
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Reglińska-Matveyev Natalia¹,Andersson Helena M.¹,Rezende Suely M.²,Dahlbäck Björn³,Crawley James T. B.¹,Lane David A.¹,Ahnström Josefin¹

Affiliation:

1. Centre for Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom;

2. Department of Internal Medicine, Faculty of Medicine, Universidade Federal de Minas Gerais, Minas Gerais, Brazil; and

3. Department of Laboratory Medicine, Faculty of Medicine, Lund University, Malmö, Sweden

Abstract

Key Points The protein S SHBG-like domain and, more specifically, its LG1 subunit are important for binding and enhancement of TFPI. TFPI binding to the protein S SHBG-like domain likely positions TFPI Kunitz domain 2 for optimal interaction with the active site of FXa.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/25/3979/1464876/3979.pdf

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5. The C-terminus of tissue factor pathway inhibitor is essential to its anticoagulant activity.;Nordfang;Biochemistry,1991

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