Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality

Author:

Sorror Mohamed L.12ORCID,Martin Paul J.12ORCID,Storb Rainer F.12ORCID,Bhatia Smita3ORCID,Maziarz Richard T.45ORCID,Pulsipher Michael A.67,Maris Michael B.8,Davis Christopher1,Deeg H. Joachim12ORCID,Lee Stephanie J.12ORCID,Maloney David G.12ORCID,Sandmaier Brenda M.12ORCID,Appelbaum Frederick R.12ORCID,Gooley Theodore A.910ORCID

Affiliation:

1. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

2. Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA;

3. City of Hope School of Medicine, Duarte, CA;

4. Center for Hematologic Malignancies, Knight Cancer Institute, and

5. Division of Hematology and Medical Oncology, Oregon Health and Science University Knight Cancer Institute, Portland, OR;

6. Division of Hematology, University of Utah School of Medicine, Salt Lake City, UT;

7. Pediatric Blood and Marrow Transplant Program, Primary Children's Medical Center, Huntsman Cancer Institute, Salt Lake City, UT;

8. Colorado Blood Cancer Institute at Presbyterian/St. Luke's Medical Center, Denver, CO;

9. Clinical Statistics Program, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

10. Department of Biostatistics, University of Washington School of Public Health, Seattle, WA

Abstract

Key Points The HCT-CI stratifies patients into 3 groups for risks of grades 3 to 4 GVHD regardless of conditioning intensity, donor, or graft types. Comorbidity burden and development of grades 2 to 4 acute GVHD have cumulative effects on mortality rates.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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