Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent-Reference-Cited by-同舟云学术

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent

Published:2014-12-04 Issue:24 Volume:124 Page:3515-3523
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lerman Yelena V.¹²,Lim Kihong¹³,Hyun Young-Min¹³,Falkner Kathleen L.⁴,Yang Hongmei⁵,Pietropaoli Anthony P.⁴,Sonnenberg Arnoud⁶,Sarangi Pranita P.¹³,Kim Minsoo¹²³

Affiliation:

1. David H. Smith Center for Vaccine Biology and Immunology,

2. Department of Pharmacology and Physiology,

3. Department of Microbiology and Immunology,

4. Pulmonary and Critical Care Medicine Division, and

5. Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY; and

6. Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

Abstract

Key Points Integrin α3β1 (VLA-3; CD49c/CD29) is significantly upregulated on neutrophils from human septic patients and mouse models of sepsis. α3β1high granulocytes displayed hyperinflammatory phenotypes and inhibition of α3β1 improved survival in septic mice.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/24/3515/1382092/3515.pdf

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