Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects

Author:

Gazendam Roel P.1,van Hamme John L.1,Tool Anton T. J.1,van Houdt Michel1,Verkuijlen Paul J. J. H.1,Herbst Martin2,Liese Johannes G.2,van de Veerdonk Frank L.3,Roos Dirk1,van den Berg Timo K.1,Kuijpers Taco W.14

Affiliation:

1. Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;

2. University Children’s Hospital, Paediatric Infectious Diseases and Immunology, University of Würzburg, Würzburg, Germany;

3. Nijmegen Center for Infection, Immunity and Inflammation (N4i), Radboud University, Nijmegen Medical Center, Nijmegen, The Netherlands; and

4. Emma Children’s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Abstract

Key Points Human neutrophils use 2 independent mechanisms for the killing of unopsonized and serum-opsonized C albicans. Unopsonized Candida killing depends on CR3 and CARD9 but not dectin-1; opsonized Candida killing on FcγR, PKC, and NADPH oxidase activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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