Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans-Reference-Cited by-同舟云学术

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans

Published:2013-03-14 Issue:11 Volume:121 Page:2074-2083
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ueki Shigeharu¹²,Melo Rossana C. N.¹³,Ghiran Ionita¹,Spencer Lisa A.¹,Dvorak Ann M.⁴,Weller Peter F.¹

Affiliation:

1. Division of Allergy and Inflammation, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA;

2. Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan;

3. Laboratory of Cellular Biology, Department of Biology, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil; and

4. Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

Abstract

Key Points This research is the first to document that human eosinophils undergo extracellular DNA trap cell death. This research revealed a process by which eosinophils undergo cytolysis to liberate intact cell-free and secretion-competent granules.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/11/2074/1364529/2074.pdf

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