Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia

Author:

Gutjahr Julia C.12,Szenes Eva12,Tschech Lisa12,Asslaber Daniela12,Schlederer Michaela3456,Roos Simone5,Yu Xiaobing7,Girbl Tamara12,Sternberg Christina8,Egle Alexander12,Aberger Fritz8,Alon Ronen9,Kenner Lukas3456,Greil Richard12,Orian-Rousseau Veronique7,Hartmann Tanja N.12ORCID

Affiliation:

1. Third Medical Department with Hematology, Medical Oncology, Hemostaseology, Infectious Diseases, and Rheumatology, Oncologic Center, Paracelsus Medical University, Salzburg, Austria;

2. Cancer Cluster Salzburg, Laboratory for Immunological and Molecular Cancer Research, Salzburg Cancer Research Institute, Salzburg, Austria;

3. Clinical Institute of Pathology and

4. Department of Experimental Pathology and Laboratory Animal Science, Medical University of Vienna, Vienna, Austria;

5. Unit of Pathology of Laboratory Animals, University of Veterinary Medicine, Vienna, Austria;

6. Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria;

7. Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany;

8. Cancer Cluster Salzburg, Department of Molecular Biology, Paris-Lodron University of Salzburg, Salzburg, Austria; and

9. Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

Abstract

Key PointsThe spleen but not bone marrow microenvironment induces CD44v6 variants in CLL, which promote early engraftment. CD44v6 expression is linked to NF-κB and MAPK signaling in murine and human B-cell leukemia and contributes to proliferation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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