Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination-Reference-Cited by-同舟云学术

Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination

Published:2018-09-13 Issue:11 Volume:132 Page:1134-1145
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Akahori Yasushi¹,Wang Linan¹,Yoneyama Motohiro¹,Seo Naohiro¹,Okumura Satoshi¹,Miyahara Yoshihiro¹,Amaishi Yasunori²,Okamoto Sachiko²,Mineno Junichi²,Ikeda Hiroaki¹³,Maki Takehiro⁴,Fujiwara Hiroshi⁵,Akatsuka Yoshiki⁶,Kato Takuma⁷⁸,Shiku Hiroshi¹⁸

Affiliation:

1. Department of Immuno-Gene Therapy, Mie University Graduate School of Medicine, Mie, Japan;

2. Takara Bio Inc., Shiga, Japan;

3. Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;

4. Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Hokkaido, Japan;

5. Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Ehime, Japan;

6. Department of Hematology and Oncology, Fujita Health University, Toyoake, Aichi, Japan;

7. Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine, Mie, Japan; and

8. Center for Comprehensive Cancer Immunotherapy, Mie University, Mie, Japan

Abstract

Key Points T cells expressing a CAR consisting of scFv #213 targeting WT1 peptide/HLA-A*2402 complex killed HLA-A*2402+ WT1+ tumor cell lines. The therapeutic efficacy of #213 scFv CAR-T cells was shown to be enhanced by DC vaccine in a murine xenograft model.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/132/11/1134/1372800/blood802926.pdf

Reference77 articles.

1. Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia;Davila;Sci Transl Med,2014

2. Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor;Kochenderfer;J Clin Oncol,2015

3. Chimeric antigen receptor T cells for sustained remissions in leukemia;Maude;N Engl J Med,2014

4. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia;Kalos;Sci Transl Med,2011

5. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial;Lee;Lancet,2015

Cited by 73 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Wilms’ tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP;PLOS Pathogens;2024-01-08

2. Preclinical evaluation of a novel CAR-T therapy utilizing a scFv antibody highly specific to MAGE-A4p230-239/HLA-A∗02:01 complex;Molecular Therapy;2024-01

3. The delicate balance of graft versus leukemia and graft versus host disease after allogeneic hematopoietic stem cell transplantation;Expert Review of Hematology;2023-11-06

4. Improving the efficacy of peptide vaccines in cancer immunotherapy;International Immunopharmacology;2023-10

5. Challenges and solutions for therapeuticTCR‐based agents;Immunological Reviews;2023-07-16