Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells-Reference-Cited by-同舟云学术

Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells

Published:2017-12-21 Issue:25 Volume:130 Page:2762-2773
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhao Xin¹²^ORCID,Gao Shouguo¹,Wu Zhijie¹²,Kajigaya Sachiko¹,Feng Xingmin¹,Liu Qingguo¹²,Townsley Danielle M.¹,Cooper James¹,Chen Jinguo³,Keyvanfar Keyvan¹,Fernandez Ibanez Maria del Pilar¹,Wang Xujing⁴,Young Neal S.¹

Affiliation:

1. Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD;

2. Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People’s Republic of China;

3. Center for Human Immunology, Autoimmunity and Inflammation, National Institutes of Health, Bethesda, MD; and

4. Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points We distinguished aneuploid cells from diploid cells within the hematopoietic stem and progenitor cells using scRNA-seq. Monosomy 7 cells showed downregulated pathways involved in immune response and maintenance of DNA stability.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/25/2762/1404292/blood803353.pdf

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