Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease-Reference-Cited by-同舟云学术

Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft-versus-host disease

Published:2017-08-17 Issue:7 Volume:130 Page:933-942
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dudakov Jarrod A.¹²³^ORCID,Mertelsmann Anna M.⁴,O’Connor Margaret H.⁴,Jenq Robert R.⁵⁶^ORCID,Velardi Enrico¹^ORCID,Young Lauren F.¹,Smith Odette M.¹,Boyd Richard L.⁷,van den Brink Marcel R. M.¹⁴⁸^ORCID,Hanash Alan M.⁴⁸^ORCID

Affiliation:

1. Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY;

2. Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

3. Department of Immunology, University of Washington, Seattle, WA;

4. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;

5. Department of Genomic Medicine and

6. Department of Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX;

7. Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia; and

8. Department of Medicine, Weill Cornell Medical College, New York, NY

Abstract

Key Points Thymic ILCs and their production of IL-22 are reduced in mice with GVHD; IL-22 deficiency worsens thymic epithelial damage in GVHD. Administration of IL-22 posttransplant can enhance thymopoiesis after experimental allogeneic bone marrow transplant.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/7/933/1367054/blood762658.pdf

Reference63 articles.

1. Strategies to enhance T-cell reconstitution in immunocompromised patients;van den Brink;Nat Rev Immunol,2004

2. Various forms of tissue damage and danger signals following hematopoietic stem-cell transplantation;Ramadan;Front Immunol,2015

3. The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease;Na;J Clin Invest,2010

4. The immunopathology of thymic GVHD;Krenger;Semin Immunopathol,2008

5. Apoptosis of thymocytes during acute graft-versus-host disease is independent of glucocorticoids;Krenger;Transplantation,2000

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