Presentation and outcome of patients with 2016 WHO diagnosis of prefibrotic and overt primary myelofibrosis

Author:

Guglielmelli Paola12ORCID,Pacilli Annalisa12,Rotunno Giada12,Rumi Elisa34,Rosti Vittorio5,Delaini Federica6,Maffioli Margherita78,Fanelli Tiziana129,Pancrazzi Alessandro12,Pietra Daniela10,Salmoiraghi Silvia6,Mannarelli Carmela12,Franci Annalisa12,Paoli Chiara12,Rambaldi Alessandro611,Passamonti Francesco78,Barosi Giovanni5,Barbui Tiziano12,Cazzola Mario34,Vannucchi Alessandro M.12ORCID

Affiliation:

1. Centro Ricerca e Innovazione delle Malattie Mieloproliferative (CRIMM), Azienda Ospedaliera–Universitaria Careggi, Firenze, Italy;

2. Department of Experimental and Clinical Medicine, DENOTHE Centre, University of Florence, Florence, Italy;

3. Department of Hematology Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy;

4. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

5. Center for the Study of Myelofibrosis, Biotechnology Research Area, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy;

6. Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy;

7. Division of Hematology, Department of Specialistic Medicine, Ospedale Azienda Socio Sanitaria Territoriale (ASST)–Sette Laghi, Varese, Italy;

8. Department of Experimental and Clinical Medicine, University of Insubria, Varese, Italy;

9. GenOMec, University of Siena, Siena, Italy;

10. Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy;

11. Department of Oncology-Hematology Università degli Studi di Milano, Milan, Italy; and

12. FROM Research Foundation, Bergamo, Italy

Abstract

Key Points Differential diagnosis of pre-PMF and overt PMF by 2016 WHO criteria underscores uniqueness in disease presentation and outcome. Patterns of driver and nondriver myeloid gene mutations contribute to prognosis in both pre-PMF and overt PMF.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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