Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers

Author:

Jawhar Mohamad12,Schwaab Juliana12,Naumann Nicole12,Horny Hans-Peter3,Sotlar Karl4,Haferlach Torsten5,Metzgeroth Georgia12,Fabarius Alice12,Valent Peter6,Hofmann Wolf-Karsten12,Cross Nicholas C. P.78,Meggendorfer Manja5,Reiter Andreas12

Affiliation:

1. Department of Hematology and Oncology, Mannheim University Medical Center, Mannheim, Germany;

2. Mannheim Medical Faculty, Heidelberg University, Heidelberg, Germany;

3. Institute of Pathology, Ludwig Maximilian University, Munich, Germany;

4. University Institute of Pathology, Salzburg University Hospital, Paracelsus Medical University, Salzburg, Austria;

5. Munich Leukemia Laboratory, Munich, Germany;

6. Division of Hematology and Ludwig Boltzmann Cluster Oncology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria;

7. Wessex Regional Genetics Laboratory, Salisbury, United Kingdom; and

8. Faculty of Medicine, University of Southampton, Southampton, United Kingdom

Abstract

Key Points The complexity and dynamics of mutations significantly impact on response, progression, and prognosis in midostaurin-treated advSM patients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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