Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

Author:

Durham Benjamin H.1,Getta Bartlomiej2,Dietrich Sascha345,Taylor Justin6,Won Helen67,Bogenberger James M.8,Scott Sasinya67,Kim Eunhee9,Chung Young Rock6,Chung Stephen S.6,Hüllein Jennifer4,Walther Tatjana4,Wang Lu1,Lu Sydney X.6,Oakes Christopher C.10,Tibes Raoul8,Haferlach Torsten11,Taylor Barry S.6712,Tallman Martin S.2,Berger Michael F.67,Park Jae H.2,Zenz Thorsten34,Abdel-Wahab Omar26ORCID

Affiliation:

1. Department of Pathology and

2. Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY;

3. Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany;

4. Department of Molecular Therapy in Hematology and Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany;

5. Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany;

6. Human Oncology and Pathogenesis Program and

7. Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY;

8. Division of Hematology and Medical Oncology, Mayo Clinic/Mayo Clinic Cancer Center, Scottsdale, AZ;

9. School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea;

10. Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH;

11. MLL Munich Leukemia Laboratory, Munich, Germany; and

12. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY

Abstract

Key Points KMT2C mutations occur in 15% and 25% of patients with cHCL and vHCL, respectively, along with CCND3 and U2AF1 mutations each in 13% of vHCLs. NF1, NF2, N/KRAS, and IRS1 alterations contribute to clinical resistance to vemurafenib treatment in patients with cHCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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