Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations-Reference-Cited by-同舟云学术

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

Published:2017-10-05 Issue:14 Volume:130 Page:1644-1648
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Durham Benjamin H.¹,Getta Bartlomiej²,Dietrich Sascha³⁴⁵,Taylor Justin⁶,Won Helen⁶⁷,Bogenberger James M.⁸,Scott Sasinya⁶⁷,Kim Eunhee⁹,Chung Young Rock⁶,Chung Stephen S.⁶,Hüllein Jennifer⁴,Walther Tatjana⁴,Wang Lu¹,Lu Sydney X.⁶,Oakes Christopher C.¹⁰,Tibes Raoul⁸,Haferlach Torsten¹¹,Taylor Barry S.⁶⁷¹²,Tallman Martin S.²,Berger Michael F.⁶⁷,Park Jae H.²,Zenz Thorsten³⁴,Abdel-Wahab Omar²⁶^ORCID

Affiliation:

1. Department of Pathology and

2. Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY;

3. Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany;

4. Department of Molecular Therapy in Hematology and Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany;

5. Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany;

6. Human Oncology and Pathogenesis Program and

7. Center for Molecular Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY;

8. Division of Hematology and Medical Oncology, Mayo Clinic/Mayo Clinic Cancer Center, Scottsdale, AZ;

9. School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea;

10. Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH;

11. MLL Munich Leukemia Laboratory, Munich, Germany; and

12. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY

Abstract

Key Points KMT2C mutations occur in 15% and 25% of patients with cHCL and vHCL, respectively, along with CCND3 and U2AF1 mutations each in 13% of vHCLs. NF1, NF2, N/KRAS, and IRS1 alterations contribute to clinical resistance to vemurafenib treatment in patients with cHCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/14/1644/1402480/blood765107.pdf

Reference28 articles.

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