Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma-Reference-Cited by-同舟云学术

Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma

Published:2017-09-21 Issue:12 Volume:130 Page:1418-1429
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Szydłowski Maciej¹,Prochorec-Sobieszek Monika²,Szumera-Ciećkiewicz Anna²,Derezińska Edyta²,Hoser Grażyna³,Wasilewska Danuta³,Szymańska-Giemza Olga²,Jabłońska Ewa¹,Białopiotrowicz Emilia¹,Sewastianik Tomasz¹,Polak Anna¹,Czardybon Wojciech⁴,Gałęzowski Michał⁴,Windak Renata⁴,Zaucha Jan Maciej⁵,Warzocha Krzysztof⁶,Brzózka Krzysztof⁴,Juszczyński Przemysław¹

Affiliation:

1. Department of Experimental Hematology and

2. Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland;

3. Laboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, Poland;

4. Selvita S.A., Cracow, Poland;

5. Department of Propedeutic Oncology, Polish Research Lymphoma Group, Medical University of Gdansk, Gdansk, Poland; and

6. Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland

Abstract

Key Points PIM kinases are ubiquitously expressed in RS cells of cHL. PIM inhibition decreases NFκB and STAT3/5 activity, cell viability, and expression of immunoregulatory proteins PD-L1/2 and galectin-1.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/12/1418/1402576/blood760702.pdf

Reference65 articles.

1. Hodgkin lymphoma;Stein,2008

2. CD40 expression in Hodgkin’s disease;O’Grady;Am J Pathol,1994

3. Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin-Reed-Sternberg cells;Horie;Oncogene,2002

4. The biology of Hodgkin’s lymphoma;Küppers;Nat Rev Cancer,2009

5. High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cells;Bargou;Blood,1996

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