PD-1 blockade for relapsed lymphoma post–allogeneic hematopoietic cell transplant: high response rate but frequent GVHD

Author:

Haverkos Bradley M.1ORCID,Abbott Diana2,Hamadani Mehdi3,Armand Philippe4,Flowers Mary E.5,Merryman Reid4,Kamdar Manali1,Kanate Abraham Sebastian6,Saad Ayman7,Mehta Amitkumar7,Ganguly Siddhartha8,Fenske Timothy S.3,Hari Parameswaran3,Lowsky Robert9,Andritsos Leslie10,Jagasia Madan11,Bashey Asad12,Brown Stacey12,Bachanova Veronika13,Stephens Deborah14,Mineishi Shin15,Nakamura Ryotaro16,Chen Yi-Bin17,Blazar Bruce R.18,Gutman Jonathan1,Devine Steven M.10

Affiliation:

1. Division of Hematology, University of Colorado School of Medicine, Denver, CO;

2. Division of Biostatistics, University of Colorado, Denver, CO;

3. Division of Hematology and Oncology, Medical College of Wisconsin and Center for International Blood and Marrow Transplant Research, Milwaukee, WI;

4. Division of Hematology, Dana-Farber Cancer Institute, Boston, MA;

5. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA;

6. Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, Morgantown, WV;

7. Blood and Marrow Transplant Program, University of Alabama at Birmingham, Birmingham, AL;

8. Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas City, KS;

9. Division of Blood and Marrow Transplantation, Stanford University, Stanford, CA;

10. Division of Hematology, The Ohio State University, Columbus, OH;

11. Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN;

12. Blood and Marrow Transplant Program, Northside Hospital, Atlanta, GA;

13. Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN;

14. Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, UT;

15. Division of Hematology, Penn State Cancer Institute, Hershey, PA;

16. Division of Hematology, City of Hope, Los Angeles, CA;

17. Massachusetts General Hospital, Boston, MA; and

18. Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN

Abstract

Key Points Checkpoint blockade via anti–PD-1 mAbs was associated with a high overall response rate in relapsed Hodgkin lymphoma allo-HCT patients. Checkpoint blockade via anti–PD-1 mAbs after allo-HCT can be complicated by rapid onset of severe and treatment-refractory GVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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