Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia-Reference-Cited by-同舟云学术

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

Published:2016-05-19 Issue:20 Volume:127 Page:2439-2450
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bellon Marcia¹,Lu Ling¹,Nicot Christophe¹

Affiliation:

1. Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, Kansas City, KS

Abstract

Key Points Epigenetic silencing of miR-124a leads to constitutive STAT3 and activation of downstream Pim1. Pim1 kinase signaling is constitutively activated in ATL cells and represents a novel therapeutic target.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/20/2439/1393812/2439.pdf

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