Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice-Reference-Cited by-同舟云学术

Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice

Published:2016-08-04 Issue:5 Volume:128 Page:721-731
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Shaw Maureen A.¹,Kombrinck Keith W.²,McElhinney Kathryn E.¹,Sweet David R.¹,Flick Matthew J.²,Palumbo Joseph S.¹,Cheng Mei³,Esmon Naomi L.³,Esmon Charles T.³,Brill Alexander⁴⁵,Wagner Denisa D.⁵^ORCID,Degen Jay L.²,Mullins Eric S.¹^ORCID

Affiliation:

1. Division of Hematology and

2. Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children’s Research Foundation, Cincinnati, OH;

3. Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK;

4. Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom; and

5. Program in Cellular and Molecular Medicine and Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA

Abstract

Key Points Mice expressing a form of prothrombin with limited activation potential to meizothrombin are viable and are reproductively successful. Meizothrombin directly activates platelets but has diminished positive regulation of hemostatic factor activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/5/721/1397783/721.pdf

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4. Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice.;Xue;Proc Natl Acad Sci USA,1998

5. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.;Flick;Blood,2011

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