IL-4 enhances expression and function of surface IgM in CLL cells-Reference-Cited by-同舟云学术

IL-4 enhances expression and function of surface IgM in CLL cells

Published:2016-06-16 Issue:24 Volume:127 Page:3015-3025
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Aguilar-Hernandez Maria M.¹,Blunt Matthew D.¹,Dobson Rachel¹,Yeomans Alison¹,Thirdborough Stephen¹,Larrayoz Marta¹,Smith Lindsay D.¹,Linley Adam¹,Strefford Jonathan C.¹,Davies Andrew²,Johnson Peter M. W.¹²,Savelyeva Natalia¹,Cragg Mark S.³,Forconi Francesco¹⁴,Packham Graham¹,Stevenson Freda K.¹,Steele Andrew J.¹^ORCID

Affiliation:

1. Cancer Research UK Centre, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom;

2. Medical Oncology, University Hospital Southampton National Health Service Trust, Southampton, United Kingdom;

3. Antibody and Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; and

4. Haematology Department, University Hospital Southampton National Health Service Trust, Southampton, United Kingdom

Abstract

Key Points IL-4 treatment augments sIgM expression and subsequent downstream signalling in a JAK3/STAT6 dependent manner within CLL samples. IL-4 exposure partially opposes the activity of Bruton tyrosine kinase or PI3K inhibitors on sIgM-mediated signalling.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/24/3015/1394579/3015.pdf

Reference63 articles.

1. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia.;Hamblin;Blood,1999

2. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia.;Damle;Blood,1999

3. B-cell receptor signaling in chronic lymphocytic leukemia.;Stevenson;Blood,2011

4. Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib.;Byrd;Blood,2015

5. Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status.;Mockridge;Blood,2007

Cited by 80 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Fibroblast‐like synoviocytes preferentially induce terminal differentiation of IgD⁺ memory B cells instead of naïve B cells;Immunology;2024-07-25

2. NK Cells in the Lymph Nodes and Their Role in Anti-Tumour Immunity;Biomedicines;2024-07-25

3. The complexities of T-cell dysfunction in chronic lymphocytic leukemia;Seminars in Hematology;2024-06

4. New Derivatives of 1-(3-Methyl-1-Benzofuran-2-yl)Ethan-1-one: Synthesis and Preliminary Studies of Biological Activity;International Journal of Molecular Sciences;2024-02-07

5. Cell crosstalk within lymphoma tumor microenvironment: follicular lymphoma as a paradigm;Blood Journal;2023-12-14