Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies-Reference-Cited by-同舟云学术

Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies

Published:2016-07-28 Issue:4 Volume:128 Page:519-528
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sabatino Marianna¹,Hu Jinhui²,Sommariva Michele¹³,Gautam Sanjivan²,Fellowes Vicki²,Hocker James D.²,Dougherty Sean²,Qin Haiying⁴,Klebanoff Christopher A.²,Fry Terry J.⁴,Gress Ronald E.²,Kochenderfer James N.²,Stroncek David F.¹,Ji Yun²,Gattinoni Luca²

Affiliation:

1. Department of Transfusion Medicine, Cell Processing Section, Clinical Center, National Institutes of Health, Bethesda, MD;

2. Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD;

3. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy; and

4. Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD

Abstract

Key Points A platform for the generation of clinical-grade CD19-CAR–modified TSCM. CD19-CAR–modified TSCM mediate superior antitumor responses compared with CD19-CAR T cells currently used in clinical trials.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/4/519/1398080/519.pdf

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