Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases

Author:

Dasgupta Yashodhara1,Koptyra Mateusz1,Hoser Grazyna2,Kantekure Kanchan3,Roy Darshan3,Gornicka Barbara4,Nieborowska-Skorska Margaret1,Bolton-Gillespie Elisabeth1,Cerny-Reiterer Sabine5,Müschen Markus6,Valent Peter5,Wasik Mariusz A.3,Richardson Christine7,Hantschel Oliver8,van der Kuip Heiko9,Stoklosa Tomasz10,Skorski Tomasz1

Affiliation:

1. Department of Microbiology & Immunology, Temple University School of Medicine, Philadelphia, PA;

2. Department of Clinical Cytology, Medical Center for Postgraduate Education, Warsaw, Poland;

3. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA;

4. Department of Pathology, Medical University of Warsaw, Warsaw, Poland;

5. Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna and Ludwig-Boltzmann Cluster Oncology, Vienna, Austria;

6. Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA;

7. Department of Biological Sciences and Center of Bioinformatics, University of North Carolina at Charlotte, Charlotte, NC;

8. Swiss Institute for Experimental Cancer Research, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland;

9. Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Stuttgart, Germany; and

10. Department of Immunology, Medical University of Warsaw, Warsaw, Poland

Abstract

Key Points Normal ABL1 is a tumor suppressor in BCR-ABL1–induced leukemia. Allosteric stimulation of the normal ABL1 kinase activity enhanced the antileukemia effect of ABL1 tyrosine kinase inhibitors.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference78 articles.

1. Role of ABL family kinases in cancer: from leukaemia to solid tumours.;Greuber;Nat Rev Cancer,2013

2. The capable ABL: what is its biological function?;Wang;Mol Cell Biol,2014

3. ABL tyrosine kinases: evolution of function, regulation, and specificity [published correction appears in Sci Signal. 2011;4(188):er4].;Colicelli;Sci Signal,2010

4. Bone marrow B lymphocyte development in c-abl-deficient mice.;Hardin;Cell Immunol,1995

5. Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations.;Schwartzberg;Cell,1991

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