Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6-Reference-Cited by-同舟云学术

Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6

Published:2016-06-09 Issue:23 Volume:127 Page:2890-2902
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Uras Iris Z.¹,Walter Gina J.²³,Scheicher Ruth¹,Bellutti Florian¹,Prchal-Murphy Michaela¹,Tigan Anca S.¹,Valent Peter⁴⁵,Heidel Florian H.⁶,Kubicek Stefan⁷,Scholl Claudia²³,Fröhling Stefan²³⁸,Sexl Veronika¹

Affiliation:

1. Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria;

2. Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany;

3. German Cancer Consortium, Heidelberg, Germany;

4. Division of Hematology and Hemostaseology, Department of Internal Medicine I, and

5. Ludwig Boltzmann Cluster Oncology, Medical University of Vienna, Vienna, Austria;

6. Department of Hematology and Oncology, Center for Internal Medicine II, Jena University Hospital, Jena, Germany;

7. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria; and

8. Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg, Germany

Abstract

Key Points CDK6 directly regulates transcription of FLT3 and PIM1 in a kinase-dependent manner. CDK6 kinase inhibition impairs not only FLT3-dependent cell growth in vitro but also FLT3-driven leukemogenesis in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/23/2890/1393605/2890.pdf

Reference69 articles.

1. Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia.;Zhou;World J Stem Cells,2014

2. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing.;Ding;Nature,2012

3. The origin and evolution of mutations in acute myeloid leukemia.;Welch;Cell,2012

4. Clonal architecture of secondary acute myeloid leukemia.;Walter;N Engl J Med,2012

5. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.;Ley;Nature,2008

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