A case for developing North-South partnerships for research in sickle cell disease

Author:

Weatherall David1,Hofman Karen1,Rodgers Griffin1,Ruffin John1,Hrynkow Sharon1

Affiliation:

1. From the Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom; Fogarty International Center, National Institutes of Health, Bethesda, MD; Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD; and National Center for Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD.

Abstract

Abstract For a better understanding of the pathophysiology and mechanisms of phenotypic diversity of sickle cell disease, and for the improvement of its management globally, there is a strong case for developing sustainable research partnerships between rich and poor countries.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference29 articles.

1. Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79: 704-712.

2. Nagel RL, Steinberg MH. Genetics of the βS gene: origins, genetic epidemiology, and epistasis in sickle cell anemia. In: Steinberg MH, Forget BG, Higgs DR, Nagel RL, eds. Disorders of Hemoglobin. Cambridge, United Kingdom: Cambridge University Press; 2001: 711-755.

3. Livingstone FB. Frequencies of Hemoglobin Variants. New York, NY: Oxford University Press; 1985.

4. World Health Organization. Guidelines for the Control of Haemoglobin Disorders. Geneva, Switzerland: World Health Organization; 1994.

5. Leikin SL, Gallagher D, Kinney TR, Sloane D, Klug P, Rida W. Mortality in children and adolescents with sickle cell disease. Cooperative Study of Sickle Cell Disease. Pediatrics. 1989;84: 500-508.

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