Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia-Reference-Cited by-同舟云学术

Genome-wide studies identify a novel interplay between AML1 and AML1/ETO in t(8;21) acute myeloid leukemia

Published:2016-01-14 Issue:2 Volume:127 Page:233-242
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Li Yizhen¹,Wang Huanwei¹,Wang Xiaoling¹,Jin Wen¹,Tan Yun¹,Fang Hai²,Chen Saijuan¹²,Chen Zhu¹²³,Wang Kankan¹²³

Affiliation:

1. State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; and

3. Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

Key Points Wild-type AML1 and AML1/ETO form a complex on chromatin via binding to adjacent different motifs and interacting through the runt homology domain. The relative binding signals of AML1/ETO and AML1 and AP-1 recruitment determine whether AML1/ETO activates or represses its targets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/2/233/1352111/233.pdf

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