Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice-Reference-Cited by-同舟云学术

Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice

Published:2014-04-03 Issue:14 Volume:123 Page:2172-2180
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Murphy Judith T.¹²,Burey Andre P.¹,Beebe Amy M.³,Gu Danling³,Presta Leonard G.³,Merghoub Taha¹,Wolchok Jedd D.¹²⁴

Affiliation:

1. Ludwig Collaborative Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY;

2. Weill Cornell Graduate School of Medical Sciences, New York, NY;

3. Merck Research Laboratories, Palo Alto, CA; and

4. Weill Cornell Medical College, New York, NY

Abstract

Key Points Repeated doses of agonist antibodies targeting the costimulatory receptors GITR and OX40 result in anaphylaxis in mice. Anaphylaxis caused by the GITR agonist antibody DTA-1 is dependent on GITR, IL-4, basophils, and platelet-activating factor.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/14/2172/1375066/2172.pdf

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