Deep molecular responses achieved in patients with CML-CP who are switched to nilotinib after long-term imatinib

Author:

Hughes Timothy P.1ORCID,Lipton Jeffrey H.2,Spector Nelson3,Cervantes Francisco4,Pasquini Ricardo5,Clementino Nelma Cristina D.6,Dorlhiac Llacer Pedro Enrique7,Schwarer Anthony P.8,Mahon Francois-Xavier9,Rea Delphine10,Branford Susan11,Purkayastha Das12,Collins LaTonya12,Szczudlo Tomasz12,Leber Brian13

Affiliation:

1. South Australian Health and Medical Research Institute, Division of Haematology and Centre for Cancer Biology, South Australia Pathology, University of Adelaide, Adelaide, Australia;

2. Princess Margaret Hospital, Leukemia Clinic, Blood and Marrow Transplant Centre, Apheresis Unit, Toronto, ON, Canada;

3. Universidade Federal do Rio de Janeiro, Department of Clinical Medicine, Rio de Janeiro, Brazil;

4. Hospital Clínic L'Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain;

5. Universidade Federal do Paraná, Hospital de Clinicas, Curitiba, Paraná, Brazil;

6. Hospital Das Clinicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;

7. Hospital das Clinicas, Faculdade de Medicina da Universidade de São Paulo, Hematology Department, São Paulo, Brazil;

8. Hematology Department, Alfred Hospital, Melbourne, Australia;

9. Laboratoire d'Hématologie, Centre Hospitalier Universitaire de Bordeaux and Laboratoire Hématopoïèse Leucémique et Cible Thérapeutique, Biothérapies des Maladies Génétiques et Cancers, Inserm U1035, Université Bordeaux Ségalen, Bordeaux, France;

10. Service des Maladies du Sang et EA3518, Hôpital Saint-Louis, Paris, France;

11. Centre for Cancer Biology, South Australia Pathology, University of Adelaide, Adelaide, Australia;

12. Novartis Pharmaceuticals Corporation, East Hanover, NJ; and

13. McMaster University and Juravinski Hospital and Cancer Centre, Hamilton, ON, Canada

Abstract

Key Points Nilotinib induced deeper molecular responses than continued imatinib in patients with minimal residual disease on long-term imatinib. These deeper responses may enable more patients to benefit from treatment-free remission trials.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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