GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice-Reference-Cited by-同舟云学术

GpIbα-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice

Published:2014-05-22 Issue:21 Volume:123 Page:3354-3363
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Le Behot Audrey¹,Gauberti Maxime¹,Martinez De Lizarrondo Sara¹,Montagne Axel¹,Lemarchand Eloïse¹,Repesse Yohann¹,Guillou Sylvain²,Denis Cécile V.³,Maubert Eric¹,Orset Cyrille¹,Vivien Denis¹

Affiliation:

1. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche Scientifique U919, “Serine Proteases and Pathophysiology of the Neurovascular Unit”, Groupement d'Intérêt Public Cyceron, Caen, France;

2. Normandie Université, Université de Caen, Laboratoire Universitaire des Sciences Appliquées de Cherbourg, EA 4253, BP 78, Cherbourg-Octeville, France; and

3. Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche Scientifique U770, Université Paris-Sud, Le Kremlin-Bicêtre, France

Abstract

Key Points Following endothelial damage, platelet cross-linking during closure of the vessel lumen is mediated by GpIbα-VWF interactions. Disruption of GpIbα-VWF interactions restores vessel patency by specifically disaggregating the external layer of occlusive thrombi.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/21/3354/1377681/3354.pdf

Reference40 articles.

1. Arterial thrombosis—insidious, unpredictable and deadly.;Jackson;Nat Med,2011

2. Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT.;Kim;Neurology,2006

3. Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence.;Vivien;J Cereb Blood Flow Metab,2011

4. Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial.;Mehilli;Circulation,2009

5. A structural and dynamic investigation of the facilitating effect of glycoprotein IIb/IIIa inhibitors in dissolving platelet-rich clots.;Collet;Circ Res,2002

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