Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients-Reference-Cited by-同舟云学术

Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients

Published:2014-10-16 Issue:16 Volume:124 Page:2544-2553
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

de Miranda Noel F. C. C.¹,Georgiou Konstantinos¹,Chen Longyun²,Wu Chenglin¹,Gao Zhibo²,Zaravinos Apostolos¹,Lisboa Susana³,Enblad Gunilla⁴,Teixeira Manuel R.³,Zeng Yixin⁵,Peng Roujun⁵,Pan-Hammarström Qiang¹⁵⁶

Affiliation:

1. Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, Huddinge, Sweden;

2. Department of Medical Sciences Research, Beijing Genomics Institute-Shenzhen, Shenzhen, China;

3. Department of Genetics, Portuguese Oncology Institute, and Abel Salazar Biomedical Sciences Institute, Porto University, Porto, Portugal;

4. Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden;

5. Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, and Collaborative Innovation Center of Cancer Medicine, Guangzhou, China; and

6. Guangzhou Institute of Respiratory Disease and China State Key Laboratory of Respiratory Disease, Guangzhou, China

Abstract

Key PointsSequencing of Chinese DLBCL reveals novel mutation targets and highlights additional/alternative tumorigenic pathways in these tumors. DTX1 is frequently mutated in Chinese DLBCL and deleterious mutations in this gene contribute to the activation of the Notch pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/16/2544/1380287/2544.pdf

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