Platelets induce apoptosis via membrane-bound FasL

Author:

Schleicher Rebecca I.12,Reichenbach Frank345,Kraft Peter6,Kumar Anil7,Lescan Mario8,Todt Franziska3,Göbel Kerstin9,Hilgendorf Ingo10,Geisler Tobias2,Bauer Axel2,Olbrich Marcus12,Schaller Martin11,Wesselborg Sebastian12,O’Reilly Lorraine13,Meuth Sven G.9,Schulze-Osthoff Klaus14,Gawaz Meinrad2,Li Xuri15,Kleinschnitz Christoph6,Edlich Frank316,Langer Harald F.12

Affiliation:

1. Department of Cardiovascular Medicine, Section for Cardioimmunology, and

2. Department of Cardiovascular Medicine, University Hospital, Eberhard Karls University, Tuebingen, Germany;

3. Institute for Biochemistry and Molecular Biology, Centre for Biochemistry and Molecular Cell Research (ZBMZ),

4. Faculty of Biology, and

5. Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany;

6. Department of Neurology, University Hospital Wuerzburg, Wuerzburg, Germany;

7. National Eye Institute, Bethesda, MD;

8. Department of Cardiovascular Surgery, University Hospital, Eberhard Karls University, Tuebingen, Germany;

9. Department of Neurology and Institute of Physiology (Neuropathophysiology), University of Muenster, Muenster, Germany;

10. Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany;

11. Department of Dermatology, University Hospital, Eberhard Karls University, Tuebingen, Germany;

12. Institute for Molecular Medicine, Heinrich-Heine University Dusseldorf, Dusseldorf, Germany;

13. The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

14. Interfaculty Institute of Biochemistry, University of Tuebingen, Tuebingen and German Cancer Consortium and German Cancer Research Center, Heidelberg, Germany;

15. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, People’s Republic of China; and

16. BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

Abstract

Key Points PLTs contribute to apoptosis in vivo and express the death receptor ligand FasL upon activation. Membrane-bound FasL mediates PLT-induced apoptosis, whereas Bax/Bak signaling is not required but reinforces PLT-induced apoptosis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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