Lower risk for serious adverse events and no increased risk for cancer after PBSC vs BM donation

Author:

Pulsipher Michael A.1,Chitphakdithai Pintip2,Logan Brent R.3,Navarro Willis H.24,Levine John E.5,Miller John P.4,Shaw Bronwen E.6,O’Donnell Paul V.7,Majhail Navneet S.28,Confer Dennis L.24

Affiliation:

1. University of Utah School of Medicine, Primary Children’s Hospital, Salt Lake City, UT;

2. Center for International Blood and Marrow Transplant Research, Minneapolis, MN;

3. Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI;

4. National Marrow Donor Program, Minneapolis, MN;

5. The University of Michigan, Ann Arbor, MI;

6. Anthony Nolan Research Institute, London, United Kingdom;

7. Fred Hutchinson Cancer Research Center, Seattle, WA; and

8. Cleveland Clinic, Cleveland, OH

Abstract

Key Points BM donors have a threefold higher risk for life-threatening, serious unexpected, or chronic adverse events vs PBSC donors (0.99% vs 0.31%). Donors receiving granulocyte colony-stimulating factor for PBSC collection had no evidence of increased risk for cancer, autoimmune illness, and stroke.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference30 articles.

1. Recovery and safety profiles of marrow and PBSC donors: experience of the National Marrow Donor Program.;Miller;Biol Blood Marrow Transplant,2008

2. Unrelated hematopoietic stem cell donors as research subjects.;King;Bone Marrow Transplant,2011

3. Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated donors: clinical and ethical considerations.;Shaw;Bone Marrow Transplant,2010

4. Acute toxicities of unrelated bone marrow versus peripheral blood stem cell donation: results of a prospective trial from the National Marrow Donor Program.;Pulsipher;Blood,2013

5. Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer unrelated peripheral blood progenitor cell donor.;Parkkali;Bone Marrow Transplant,1996

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