miR-142-3p acts as an essential modulator of neutrophil development in zebrafish

Author:

Fan Hong-Bo12,Liu Yi-Jie13,Wang Lei12,Du Ting-Ting12,Dong Mei12,Gao Li12,Meng Zhao-Zheng12,Jin Yi12,Chen Yi12,Deng Min12,Yang Huang-Tian12,Jing Qing12,Gu Ai-Hua4,Liu Ting-Xi12,Zhou Yong12

Affiliation:

1. Key Laboratory of Stem Cell Biology and State Key Laboratory for Medical Genomics and Laboratory of Development and Diseases, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and

2. Shanghai Institute of Hematology, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

3. Department of Laboratory Medicine, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, China; and

4. State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China

Abstract

Key Points The miR-142-3p double mutant zebrafish displayed aberrant neutrophil hypermaturation and homeostasis in myelopoiesis. Abnormal activation of IFN-γ signaling mediated the impaired neutrophil development in miR-142-3p–deficient zebrafish.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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