Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response-Reference-Cited by-同舟云学术

Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response

Published:2014-06-26 Issue:26 Volume:123 Page:4045-4053
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ozelo Margareth C.¹²,Vidal Barbara¹,Brown Christine¹,Notley Colleen¹,Hegadorn Carol¹,Webster Sandra¹,Harpell Lori¹,Ahlin James¹,Winterborn Andrew¹,Handforth Janine¹,Arruda Valder R.³,Hough Christine¹,Lillicrap David¹

Affiliation:

1. Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON, Canada;

2. Instituto Nacional de Tecnologi do Sangue Hemocentro, University of Campinas, Campinas, São Paulo, Brazil; and

3. Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA

Abstract

Key Points Implanting autologous FVIII-expressing BOECs results in sustained FVIII antigen in hemophilia dogs. Anti-FVIII immunoglobulin G2 antibodies develop.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/26/4045/1377974/4045.pdf

Reference44 articles.

1. Adenovirus-associated virus vector-mediated gene transfer in hemophilia B.;Nathwani;N Engl J Med,2011

2. Expression of the blood-clotting factor-VIII cDNA is repressed by a transcriptional silencer located in its coding region.;Hoeben;Blood,1995

3. Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production.;Lynch;Hum Gene Ther,1993

4. LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway.;Zhang;J Biol Chem,2005

5. Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin.;Pipe;J Biol Chem,1998

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. DNA base editing corrects common hemophilia A mutations and restores factor VIII expression in in vitro and ex vivo models;Journal of Thrombosis and Haemostasis;2024-08

2. Potentials of Endothelial Colony-Forming Cells: Applications in Hemostasis and Thrombosis Disorders, from Unveiling Disease Pathophysiology to Cell Therapy;Hämostaseologie;2023-10

3. Myocardial Iba1, MHC class II, and CD3 are diffusely increased in canine myocarditis: A step toward antemortem myocarditis diagnostics;Veterinary Pathology;2022-06-07

4. Development of alternative gene transfer techniques for ex vivo and in vivo gene therapy in a canine model;Regenerative Therapy;2021-12

5. Efficient and safe correction of hemophilia A by lentiviral vector-transduced BOECs in an implantable device;Molecular Therapy - Methods & Clinical Development;2021-12