Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome-Reference-Cited by-同舟云学术

Mutations in TLR/MYD88 pathway identify a subset of young chronic lymphocytic leukemia patients with favorable outcome

Published:2014-06-12 Issue:24 Volume:123 Page:3790-3796
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Martínez-Trillos Alejandra¹,Pinyol Magda²,Navarro Alba²,Aymerich Marta¹,Jares Pedro²,Juan Manel³,Rozman María¹,Colomer Dolors¹,Delgado Julio⁴,Giné Eva⁴,González-Díaz Marcos⁵,Hernández-Rivas Jesús M.⁵,Colado Enrique⁶,Rayón Consolación⁶,Payer Angel R.⁶,Terol Maria José⁷,Navarro Blanca⁷,Quesada Victor⁸,Puente Xosé S.⁸,Rozman Ciril⁹,López-Otín Carlos⁸,Campo Elías¹¹⁰,López-Guillermo Armando⁴,Villamor Neus¹

Affiliation:

1. Unitat d’Hematopatologia, Servei d’Anatomia Patològica, Hospital Clínic de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and

2. Unitat de Genòmica, IDIBAPS, Barcelona, Spain;

3. Servei d’Inmunologia, and

4. Servei d’Hematologia, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain;

5. Servicio de Hematología, Hospital Clínico Universitario, Instituto de Biología molecular y celular del Cancer de Salamanca, Instituto de investigación Biomédica de Salamanca, Centro de Investigación del Cancer, Universidad de Salamanca, Salamanca, Spain;

6. Servicio de Hematología, Hospital Universitario Central de Asturias, Asturias, Spain;

7. Servicio de Hematología, Hospital Clínico de Valencia, Valencia, Spain;

8. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Asturias, Spain;

9. Josep Carreras Leukemia Research Institute, Barcelona, Spain; and

10. Universitat de Barcelona, Barcelona, Spain

Abstract

Key Points Mutations in the TLR/MYD88 pathway occur in 4% of patients with CLL, and they are the most frequent in young patients. TLR/MYD88 mutations in CLL patients confer a good outcome, which is similar to that of the age- and gender-matched healthy population.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3790/1378029/3790.pdf

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