Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells-Reference-Cited by-同舟云学术

Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells

Published:2014-06-12 Issue:24 Volume:123 Page:3780-3789
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

El-Mabhouh Amal A.¹,Ayres Mary L.¹,Shpall Elizabeth J.²,Baladandayuthapani Veerabhadran³,Keating Michael J.⁴,Wierda William G.⁴,Gandhi Varsha¹⁴^ORCID

Affiliation:

1. Department of Experimental Therapeutics,

2. Department of Stem Cell Transplantation,

3. Department of Biostatistics, and

4. Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX

Abstract

Key Points The fludarabine and bendamustine combination is cytotoxic to CLL cells even in the presence of a protective microenvironment. H2AX activation was maximum with the combination, and unscheduled DNA synthesis induced by bendamustine was blocked by fludarabine.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3780/1377844/3780.pdf

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