Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells-Reference-Cited by-同舟云学术

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells

Published:2014-08-07 Issue:6 Volume:124 Page:913-923
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Wang Cathy X.¹,Sather Blythe D.²,Wang Xuefeng²,Adair Jennifer³,Khan Iram²,Singh Swati²,Lang Shanshan¹,Adams Amie³,Curinga Gabrielle²,Kiem Hans-Peter³,Miao Carol H.²,Rawlings David J.²⁴,Torbett Bruce E.¹

Affiliation:

1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA;

2. Seattle Children’s Research Institute, Seattle, WA;

3. Fred Hutchinson Cancer Research Center, Seattle, WA; and

4. Department of Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA

Abstract

Key PointsRapamycin significantly enhances lentiviral vector gene delivery to hematopoietic stem cells while preserving engraftment potential. Rapamycin-mediated transduction enhancement is not accompanied by alterations in lentiviral integration profile.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/6/913/1382410/913.pdf

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4. Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors.;Case;Proc Natl Acad Sci USA,1999

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